Discover how Cryomedics is revolutionizing thermal regulation with its Cryo-1 device, offering new solutions for heat stress, hormonal changes, and athletic performance.
For many women, perimenopause does not begin in their 50s. It can start as early as the late 30s or early 40s, often years before menopause is formally recognized or discussed. Despite affecting roughly half of the population over a lifetime, perimenopause and menopause have historically been under-researched, under-discussed, and under-supported.
One of the most common and disruptive symptoms is hot flashes and sudden temperature swings. Studies estimate that up to 75 percent of women experience vasomotor symptoms such as hot flashes, with many reporting that symptoms last seven to ten years or longer. These episodes can interfere with sleep, work, exercise, and daily life, yet many women are told to simply tolerate them or rely on medication as the primary option.
Cryomedics is part of a growing shift toward practical, non-hormonal approaches to managing temperature dysregulation during perimenopause and menopause. Its flagship device, Cryo-1, is a handheld palm cooling and warming device designed to help women regulate sudden changes in body temperature in real time.
Why Temperature Regulation Matters in Perimenopause
During perimenopause, hormonal fluctuations can disrupt the body’s ability to regulate internal temperature. This can trigger sudden heat sensations, sweating, and discomfort that arrive with little warning. While hot flashes are often discussed as a single symptom, they are fundamentally a thermoregulation issue.
Cryo-1 addresses this by targeting the palms, an area of the body that plays a key role in heat exchange. The device delivers controlled cooling or warming directly to the hands, allowing heat to move more efficiently in or out of the bloodstream.
This approach is grounded in more than two decades of peer-reviewed research from Stanford University, where scientists identified specialized blood vessels in the palms called arteriovenous anastomoses, or AVAs. These vessels act like natural radiators, enabling rapid changes in core body temperature when properly stimulated.
From Performance Science to Women’s Health
The science behind palm cooling has been well studied in athletic and occupational settings. Stanford research has shown that targeted palm cooling can slow the rise of core body temperature and significantly increase work output and endurance in physically demanding environments.
What is now emerging is the relevance of this same mechanism for women experiencing perimenopause and menopause. By applying proven thermoregulation science to an underserved population, Cryomedics is helping bridge a long-standing gap between academic research and everyday women’s health needs.
Luke Tipple, founder of Cryomedics, explains that this realization changed the company’s direction.
“Cryo-1 was originally developed with athletes in mind,” Tipple says. “But when my wife began using the device to manage hot flashes, it became clear that this technology could support far more people. We saw an opportunity to take something validated in performance science and apply it to a real, unmet need in women’s health.”
Making Perimenopause Visible and Supported
For Aria Johnson, co-founder of Cryomedics, the mission is deeply personal.
“Perimenopausal hot flashes can start in the mid 30s, and they affect millions of women. Yet women are still expected to manage them quietly and push through. Cryomedics was born from a simple truth: if we can help athletes regulate core temperature in real time, we can help women navigate sudden temperature swings too. This technology changed my life, and it made something clear. Perimenopause is not a private problem. It is a real health reality, and women deserve a visible, science backed solution.”
As awareness grows, perimenopause and menopause are increasingly being recognized as quality-of-life and workplace issues, not just private health concerns. In June 2025, Rhode Island became the first U.S. state to enact a law explicitly classifying menopause as a protected condition requiring reasonable workplace accommodations, with additional employee notice requirements taking effect in January 2026. More recently, Philadelphia passed an ordinance in December 2025 mandating menopause-related workplace accommodations, set to take effect in 2027, while states including New York, New Jersey, and Massachusetts are actively advancing similar legislation.
These policy changes reflect a broader acknowledgment that menopausal symptoms can significantly affect comfort, productivity, and well-being at work. Yet many employers still lack practical guidance on how to provide meaningful accommodations. Cryomedics believes tools like Cryo-1 offer a simple, scalable solution, allowing workplaces to keep a number of devices on hand so employees can access fast, discreet temperature relief when needed.
By offering a non-pharmaceutical option that can be used immediately and privately, Cryo-1 helps employers meet emerging accommodation expectations while supporting women in managing temperature changes at work, at home, or on the go.
A Non-Hormonal Option for Everyday Use
Unlike bulky cooling equipment or medication-based approaches, Cryo-1 is compact, portable, and easy to use. Women can keep it nearby and activate it the moment a hot flash begins, without planning ahead or interrupting their day.
By focusing on temperature regulation rather than symptom suppression, Cryomedics is reframing how perimenopause and menopause can be supported. The company’s goal is not to replace medical care, but to give women an additional tool to regain comfort and control during a stage of life that affects millions.
Looking Ahead
As conversations around menopause continue to move into the mainstream, demand is growing for solutions that are accessible, science-backed, and non-invasive. Cryomedics is committed to expanding awareness, continuing research, and developing tools that help women better manage their body’s response to heat.
By applying proven thermoregulation science to an often-overlooked population, Cryomedics is helping redefine what support during perimenopause and menopause can look like.
Join the Cryomedics Movement Today
Are you ready to take control of your body’s temperature with a simple, science-backed device? Cryo-1 can help you stay cool, warm, and comfortable, no matter what life throws your way. Whether you’re an athlete, dealing with hot flashes, or just looking for a better way to manage heat stress, Cryomedics has a solution for you.
Learn more about Cryomedics and Cryo-1and start experiencing the power of thermal regulation today.
